Effect of Tourniquet on Sensory Nerve Conduction Threshold (sNCT) and OxyNeuroGram (ONG) Index- A Volunteer Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01970839

Enrollment

Registered

2013-10-28

Start date

2014-11-30

Completion date

2016-04-30

Last updated

2017-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oxyneurogram Index, Sensory Nerve Conduction

Keywords

Tourniquet, Endoneural, Ischemia

Brief summary

There are a number of risk factors for development of chronic pain that have been evaluated including age, gender, type and duration of surgery, duration of pain prior to surgery and tourniquet application. There is some scientific evidence from animal studies demonstrating that prolonged tourniquet application can result in lack of oxygen supply to nerves, and subsequent nerve damage resulting in chronic pain. This theory has not been proven in humans. In this study the investigators will indirectly assess the evidence for abnormalities caused by tourniquet application on subjects' nerves using well established devices to determine the function of these nerves.

Interventions

DEVICEtourniquet, sensory nerve conduction abnormality

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy adults * Over 18 years of age

Exclusion criteria

* Neurological disease * Diabetes mellitus * History of nerve injury * Chronic pain * Alcoholism * Blood pressure measurements greater than 140/80 and infection in the monitored area

Design outcomes

Primary

Measure	Time frame
Changes in sensory nerve conduction	baseline, 5 minutes
Changes in oxyneurogram index	baseline, 5 minutes

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026