Probiotics and Recovery From Surgery

Effect of Perioperative Probiotics on Clinical Outcomes of Patients Undergoing Major Abdominal Operation in Community Settings.

Status

Terminated

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01970683

Acronym

PROGRESS

Enrollment

140

Registered

2013-10-28

Start date

2014-08-31

Completion date

2017-02-28

Last updated

2017-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Abdominal Operation

Brief summary

The study will investigate whether probiotics given just before and shortly after major abdominal operation improve outcomes.

Detailed description

Perioperative probiotic intervention is associated with approximately 30% reduction of primary outcome measure.

Interventions

DIETARY_SUPPLEMENTVSL #3 BID

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* All elective major GI surgical patients

Exclusion criteria

* • Current episode of acute pancreatitis as defined by clinician * Active medication-induced immunosuppression including systemic corticosteroids, chemotherapy within 4 weeks, immunomodulating agents with transplant indication, biologicals for rheumatoid arthritis and inflammatory bowel disease. Topical chemotherapy or corticosteroids, and chemotherapy applied during operation are allowed.

Design outcomes

Primary

Measure	Time frame
30-day postsurgical outcome including death, infection, readmission	within 30 days after surgery

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026