Type 2 Diabetes
Conditions
Brief summary
Patients with diabetes have a higher incidence of heart failure and worse outcomes than normoglycaemic subjects. Basic science research has suggested many mechanisms for this observation including endothelial dysfunction, abnormal calcium handling, fibrosis and activation of the renin-angiotensin-aldosterone system (RAAS), but clinical data are lacking. In this study the investigators will investigate the relationship between diabetes and heart failure by exploring the correlation between microvascular dysfunction and cardiac magnetic resonance (CMR) markers of left ventricular (LV) hypertrophy, cardiac dysfunction and fibrosis. The investigators also propose to see if this relationship is independent of blood pressure and markers of RAAS activity. This could have important clinical ramifications in type 2 diabetes by increasing the indications for treatment with RAAS inhibition or making a case for lower blood pressure targets.
Interventions
None listed
Sponsors
Dr. Peter Swoboda
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes
Exclusion criteria
* Known cardiac or renal disease * Uncontrolled hypertension * Treatment with ACEi/ARB * Treatment with insulin * Contraindication to CMR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricle mass | One year |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricle function | 1 year |
| RAAS activity | 1 year |
Countries
United Kingdom
Outcome results
None listed