Acne Vulgaris
Conditions
Brief summary
The objective of this study is to assess the effect of a low-glycemic-load and milk-free diet on acne severity. IGF-1 and a phosphorylated product of the mTORC pathway (p70S6K) will be assessed in both groups to explore the mTORC signaling pathway, which is thought to be related to clinical improvement in previous studies.
Interventions
OTHERLow-glycemic-load and milk-free diet
Sponsors
Parc Taulí Hospital Universitari
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
14 Years to 20 Years
Healthy volunteers
No
Inclusion criteria
* Mild, moderate or severe acne (GAGS score 15-44) * Age: 14-20 years old * Presence of acne for at least 2 months
Exclusion criteria
* Diabetes * Polycystic ovary syndrome * Use of hormonal contraceptives * Previous use of oral retinoids * Use of oral antibiotics or topical antibacterial or retinoid agents in the last 2 months * Use of medications known to cause or exacerbate acne including lithium, oral or injected retinoids, some anticonvulsant drugs, medications containing iodides or bromides * Drug or alcohol abuse. * Active smokers * Anticipated difficulty attending visits or fear of blood draws
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GAGS Acne severity scale | 13 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum insulin like growth factor 1 (IGF-1) | 13 weeks | — |
| Diet acceptability and adherence | 13 weeks | — |
| p70S6K | 13 weeks | A phosphorylated product of mTORC signaling pathway |
Countries
Spain
Contacts
Primary ContactLorena Leal, Medical Doctor
Outcome results
None listed