Vascular Aging
Conditions
Brief summary
The proposed study will assess the ability of curcumin, the active ingredient in the Indian spice tumeric, to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.
Interventions
DRUGPlacebo pill
sugar and other inert substances
DRUGHigh-dose curcumin pill
2000mg curcumin pill/day
DRUGLow-dose curcumin pill
500mg curcumin pill/day
Sponsors
University of Colorado, Boulder
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* women must be postmenopausal * body mass index (BMI) \<40 kg/m2 * weight stable in the prior 3 months * absence of clinical disease as determined by medical history, physical examination, blood and urine chemistries, ankle-brachial index, and a graded exercise stress test with monitoring of blood pressure and 12-lead ECG
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial Stiffness | 12 weeks | Arterial pulse wave velocity |
| Nitric-oxide mediated endothelium-dependent dilation | 12 weeks | flow-mediated dilation and forearm blood flow responses to acetylcholine in the presence and absence of N'-monomethyl-L-arginine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Systemic oxidative stress and inflammation | 12 weeks | circulating markers of oxidative stress and inflammation |
| Endothelial cell oxidative stress and inflammation | 12 weeks | inflammatory and oxidative stress markers in biopsied vascular and arterial endothelial cells |
Countries
United States
Outcome results
None listed