The Effect of Chronic Anemia on Safety Period of Tracheal Intubation in Gynecology Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01968525

Enrollment

Registered

2013-10-24

Start date

2013-04-30

Completion date

2013-09-30

Last updated

2013-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Anemia

Keywords

anemia, non-hypoxic apnoea, tracheal intubation, anesthesia

Brief summary

1. Every individual receiving a general anesthetic is at potential risk for developing a ''cannot intubate-cannot ventilate'' situation following anesthetic induction. 2. Building up of oxygen reserves assumes great significance as this provides a longer duration of non-hypoxic apnea should one be faced with an unanticipated difficult airway. 3. The main physiological functions of red blood cell hemoglobin are to deliver oxygen to the peripheral tissues. 4. During anemia, a reduction in blood oxygen content occurs as a result of reduced Hb while arterial oxygenation and oxyhemoglobin saturation remain high. 5. Previous studies about the duration of non-hypoxic apnoea focus on methods to improve the safety period of tracheal intubation. 6. To our knowledge, there is no literature about the duration of non-hypoxic apnoea of anemia patients. 7. The aim of this study was to assess the effect of chronic anemia on the duration of non-hypoxic apnoea during induction of anaesthesia.

Detailed description

After breathing for 3 minutes, anesthesia induction was conducted. The endotracheal tube position was confirmed after anesthesia induction. Patients were left apneic with the endotracheal tube open to room air. The non-hypoxic apneic period was recorded as the time (in seconds) taken for the drop in pulse saturation to 90% or an apneic period of 10 min elapsed, whichever was earlier.

Interventions

BIOLOGICALpre-oxygen

3 min of preoxygenation before anesthesia induction.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

1. patients scheduled to undergo general anesthesia 2. American Society of Anesthesiologists Performance Status 1-2 3. adults

Exclusion criteria

1. Individuals with significant cardiorespiratory or cerebrovascular disease, 2. difficult intubation 3. history of epilepsy 4. body mass index \>25 kg/m2, 5. and those who had smoking history in past 6 months

Design outcomes

Primary

Measure	Time frame
duration of non-hypoxic apnoea	up to 6 months

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026