Attention Deficit Hyperactivity Disorder
Conditions
Keywords
Attention Deficit Hyperactivity Disorder (ADHD);, Transcranial Direct Current Stimulation (tDCS);, Control Inhibitory;, Quantitative electroencephalography;, Functional Brain Network;, Go/No Go test.
Brief summary
Evaluating neurobiological disorder associated with Attention Deficit Hyperactivity Disorder (ADHD) and the contribution of transcranial direct current stimulation (tDCS) in the adaptation of inhibitory control.
Detailed description
1. Assess the neurobiological aspects evidenced by the amount of brain electrical activity observed by the amplitude of waves through graphs in patients with ADHD, using quantitative electroencephalography; 2. Study the contribution of transcranial direct current stimulation compared with sham in the adequacy of inhibitory control in ADHD patients through neuropsychological test-Go/No Go; 3. Assessing the efficacy of tDCS in neurobiological parameters evidenced by quantitative EEG in patients with ADHD; 4. Perform the Reconstruction of the Functional Brain Network of each subject based on the quantitative EEG data through computational and mathematical modeling; 5. Register indicators of quality of life in adults with Attention Deficit Hyperactivity Disorder through the Quality of Life Questionnaire for Adults with ADHD (AAQoL).
Interventions
DEVICETranscranial Direct Current Stimulation
This technique consists in the use of low voltage electric current to increase or reduce neuronal excitability in the area stimulated. This is a non-invasive and safe intervention having infrequent and insignificant side effects characterized by mild local discomfort, itching, tingling and/or headache of short term.
DEVICESham
Same character of Transcranial Direct Current Stimulation but without current
Sponsors
Federal University of Bahia
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Signature of the informed consent; * Diagnosis of Attention Deficit Hyperactivity Disorder based on DSM-IV-TR and Adult Self-Report Scale (ASRS-18); * Adequate eyesight and hearing (or usual corrective methods such as glasses or hearing aid) that allows performing neuropsychological test and questionnaires; * Residents in Bahia/Brazil; * Over 18 years.
Exclusion criteria
* Major psychiatric disorders such as schizophrenia and bipolar disorder; * Inability to understand the questionnaires used or illiterate; * Abuse of psychoactive substances, except nicotine and caffeine, in the last 12 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantitative electroencephalography | During the only day of the assessment, we will do it before (during 8 minutes) and after (during 8 minutes more) tDCS | Quantitative electroencephalography to assess the neurobiological aspects evidenced by the amount of brain electrical activity observed by the amplitude of waves through graphs. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional Brain Network | During the only day of the assessment, we will do it before and after tDCS | Functional Brain Network based on the quantitative EEG data through computational and mathematical modeling. During the only day of the assessment, we will do it before (we will get this information from EEG recording during 8 minutes before do the stimulation) and after tDCS(we will get this information from EEG recording during 8 minutes after the stimulation). |
Other
| Measure | Time frame | Description |
|---|---|---|
| Go/No Go test | During the only day of the assessment, we will do it before and after tDCS | Neuropsychological test to assess the adequacy of inhibitory control. During the only day of the assessment, we will do it before (after 5 minutes of EEG recording, we will start the Go/No go test keeping the EEG recording for 3 minutes, and after it we will do tDCS) and after the tDCS (after 5 minutes of EEG recording, we will restart the Go/No go test keeping the EEG recording for 3 minutes). |
Countries
Brazil
Outcome results
None listed