Cardiac Arrest, Heart Arrest
Conditions
Keywords
glucose, cardiac arrest, resuscitation, insulin, GLP-1
Brief summary
The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1). Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples. Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.
Interventions
None listed
Sponsors
Helsinki University Central Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥18 years * witnessed cardiac arrest * interval form emergency call to return of spontaneous circulation 10-45 minutes
Exclusion criteria
* severe pre-arrest disability leading to withdrawing treatment in prehospital phase * no concent from next of kin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in level of insulin | 60 minutes |
| Change in level of glucagon | 60 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Blood cortisol level | 60 minutes after ROSC |
| Blood interleukin-6 level | 60 minutes after ROSC |
| Change in blood glucose level | 60 minutes |
| Change in level of GLP-1 | 60 minutes |
Countries
Finland
Outcome results
None listed