Acute Respiratory Failure
Conditions
Keywords
mechanical ventilation, weaning, acute respiratory failure, weaning failure, lung ultrasound
Brief summary
The present study aims to evaluate the impact of a weaning strategy based on identification of early signs of respiratory distress by lung ultrasound and the consequent implementation of a clinical optimization protocol as compared to usual care.
Interventions
OTHERweaning guided by LUS (lung ultrasound)
Predictive early signs of respiratory distress are assessed by lung ultrasound (LUS score \>14) and if present will trigger protocolised intervention (eg- fluid balance,diuretics, thoracocentesis, antibiotics when required \[CPIS\>6\], hemglobin\>8g/dl triggers transfusion)
Sponsors
Hospital Sirio-Libanes
University of Sao Paulo
Hospital Israelita Albert Einstein
D'Or Institute for Research and Education
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Mechanically ventilated \>48h
Exclusion criteria
* Moderate/Severe COPD * Spinal cord lesion * Neuromuscular disease (previous) * Lung fibrosis * Tracheostomy * Heart failure (EF\<50%) * Lung/pleural cancer * inadequate windowfor LUS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory distress requiring re-intubation or non-invasive ventilation | 48hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 28-day mortality | 28 days | — |
| Hospital Mortality | Hospital death/discharge (up to 60 days) | — |
| Adverse events | 48h | Renal dysfunction, complications of thoracocentesis, hydro-electrolite changes, hypotension |
Countries
Brazil
Outcome results
None listed