Intubating Conditions, Performance With Respiratory Exercise Device, Postoperative Myalgia
Conditions
Keywords
Succinylcholine, Mivacurium, Rigid Bronchoscopy, Intubating conditions, Short Procedure
Brief summary
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A alternative is the application of low dose mivacurium, reversed with neostigmine. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), patient satisfaction and the postoperative performance with respiration exercise device for these two muscle relaxants.
Interventions
DRUGSuccinylcholine
Anaesthesia was induced and maintained with propofol(1-2mg/kg and 5mg/kg/h) and remifentanil (1µg/kg and 0,2µ/kg/min). The study arm is immobilized and a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. the patients receive the muscle relaxant according to the study group.
DRUGMivacurium
Anaesthesia was induced and maintained with propofol(1-2mg/kg and 5mg/kg/h) and remifentanil (1µg/kg and 0,2µ/kg/min). The study arm is immobilized and a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. the patients receive the muscle relaxant according to the study group.
Sponsors
Dr. Horst Schmidt Klinik GmbH
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \> 18 yr * scheduled for elective rigid bronchoscopy
Exclusion criteria
* known neuromuscular disease * significant hepatic or renal dysfunction * family history of malignant hyperthermia * known allergy to one of the drugs used in this protocol * pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intubating condition | After induction of general anaesthesia (after 3-5 minutes) | For measuring the intubation conditions the scoring system proposed for Good clinical Research Practice using the following variables is used: conditions of inserting the rigid bronchoscope, vocal cord position and coughing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Myalgia | 72 hours after intervention | The severity of POM was measured using a four point scale: 0=no myalgia 1. minor pain limited to one area of the body 2. muscle pain or stiffness noticed spontaneously by the patient, which may have required analgesic therapy 3. generalized, severe or incapacitating discomfort |
| postintervention performance with a expiration exercise device | 72 hours after intervention | The performance with a respiration exercise device, which measures the expirational volume, before and after intervention. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Patient satisfaction | 72 hours after intervention | Measurement on a numeric ten point scale (10=totally satisfied) |
Countries
Germany
Outcome results
None listed