First Recently-diagnosed Colorectal Cancer
Conditions
Brief summary
The aim of the study is to establish the existence of a relationship between the dietary intake of polyunsaturated fatty acids (PUFA) and the risk of colorectal cancer in humans, using 2 reliable and complementary biomarkers: the fatty acid-composition of lipids of the abdominal subcutaneous adipose tissue and the fatty acid composition of erythrocyte phospholipids.
Interventions
OTHERBlood sample
OTHERtissue samples from abdominal subcutaneous adipose
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Eligibility
Sex/Gender
ALL
Age
45 Years to No maximum
Inclusion criteria
CASES * Patients aged ≥ 45 years * with a first recently-diagnosed colorectal cancer * due to undergo elective surgical resection with curative intent (in practice, stage I, II, III or IV if there was only one hepatic nodule that was resected with curative intent) in one of the 5 following digestive surgery units: CHU de Dijon, CHU de Nancy, CHU de Strasbourg, CHU de Reims et CHU and Besançon. * who have given their informed consent CONTROLS * Patients aged ≥ 45 years * due to undergo surgery for a benign abdominal disease (sigmoid diverticulitis, appendectomy, hiatal hernia …) * matched for abdominal site with cases for age (± 3 years), sex and hospital * Who have given their informed consent
Exclusion criteria
CASES * pre-operative anticancer treatment (chemo or radiotherapy) * existence of visceral metastases except a single hepatic nodule resected with curative intent * familial adenomatous polyposis and HNPCC syndrome (when suspected: inclusion after complementary tumor phenotype study: screening for microsatellite instability and/or immunohistochemistry study of the expression of DNA mismatch repair proteins. * known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease) * personal history (recent or not) of colorectal cancer * emergency treatment for the presenting complication (perforation, occlusion…) * significant modification in dietary habits during the previous three months * other evolving neoplastic disease * psychic state incompatible with understanding the modalities and the aims of the study (notably patients under guardianship) * pregnant or breast-feeding women CONTROLS * personal history of cancer or adenomatous colorectal polyps, * emergency intervention * known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease) * personal history (recent or not) of colorectal cancer * emergency treatment for the presenting complication (perforation, occlusion…) * significant modification in dietary habits during the previous three months * evolving neoplastic disease * psychic state incompatible with understanding the modalities and the aims of the study (notably patients under guardianship) * pregnant or breast-feeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure of polyunsaturated fatty acids in adipose tissue lipids. | baselines |
Countries
France
Outcome results
None listed