Preload Dependence During Prone Position In ARDS Patients

Evaluation of Performance Diagnosis of Hemodynamic Parameters of Preload Dependence in ARDS Patients During Prone Position

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01965574

Acronym

PRD-ARDS-PP

Enrollment

Registered

2013-10-18

Start date

2013-10-31

Completion date

2017-01-31

Last updated

2025-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS PATIENTS WITH HEMODYNAMIC INSTABILITY

Keywords

ARDS - FLUID LOADING - PRELOAD DEPENDENCE

Brief summary

Preload dependence assessment is difficult during prone position, and to date, no hemodynamic parameters have been validated to rationalize fluid loading in that position. This study aims to validate several hemodynamic parameters, using continuous cardiac output by pulse contour analysis and transpulmonary thermodilution.

Interventions

PROCEDURETrendelenburg position

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* ARDS patient * mechanically ventilated in prone position * sedated and paralyzed * with continuous cardiac output monitoring by transpulmonary thermodilution and pulse contour analysis * fluid loading as indicated by attending physician

Exclusion criteria

* Age below 18 * no affiliation to social security * Vena cava obstruction * previous inclusion in protocol

Design outcomes

Primary

Measure	Time frame	Description
Area under ROC curve of the variation in continuous cardiac output during Trendelenburg position, to detect preload dependence	1 minute after Trendelenburg position onset.	Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%

Secondary

Measure	Time frame	Description
Area under ROC curve of the variation in continuous cardiac output during end-expiratory occlusion to detect preload dependence	15 seconds after the onset of end-expiratory occlusion	Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%
Area under ROC curve of the respiratory variation in pulse pressure to detect preload dependence	1 minute after tidal volume increase to 8 ml/kg	Preload dependence is assessed by the response in cardiac output to a 500 mL fluid loading, and is deemed positive if cardiac output increase by at least 15%

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026