Relevance of the Peripheral Cholinesterase-activity on Neurocognitive Dysfunctions in Surgical Patients

Conditions

Postoperative Delirium

Keywords

Nursing Delirium Screening Scale,, Acetylcholinesterase Activity

Brief summary

In this prospective, multicenter observational study the investigators capture the perioperative course of peripheral cholinesterase activity. The focus is the perioperative inflammation causing postoperative delirium. Therefore we measure the activity of Acetylcholine-Esterase and Butyrylcholine-Esterase in whole blood of adults in the perioperative context. Early postoperative delirium will be detected by Nu-DESC in the Recovery Room or the Postanaesthesia-Care-Unit. The course of the peripheral cholinesterase activity will be compared with the incidence of postoperative delirium and other clinical dysfunctions. We follow up the patients for up to five years regarding Delirum, comorbidities and mortality data.

Anja Heymann, Martin Susewind, Nathalie M. Schneider, Leonie Liederwald, Claudia Spies et al. (7 authors)

Bariatric Surgical Practice and Patient Care2022-12-281 citations

10.1089/bari.2022.0006

Butyrylcholinesterase as a perioperative complication marker in patients after transcatheter aortic valve implantation: a prospective observational study

Bernhard Michels, Andreas Holzamer, Bernhard Gräf, Andre Bredthauer, Walter Petermichl et al. (8 authors)

BMJ Open2021-07-0122 citations

10.1136/bmjopen-2020-042857

Relevance of peripheral cholinesterase activity on postoperative delirium in adult surgical patients (CESARO)

Anika Mueller, Maria Heinrich, Anja Heymann, Peter Zahn, Konstanze Plaschke et al. (13 authors)

European Journal of Anaesthesiology2018-11-1457 citations

10.1097/eja.0000000000000888

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Male and female patients with age 18 years and above scheduled for surgery with planned stay in Recovery Room or Postanesthesia-Care-Unit * Offered patient information and written informed consent * In-hospital stay for at least 24 hours

Exclusion criteria

* Patients with known pseudocholinesterase deficiency * Participation in prospective intervention studies during the study period * Analphabetism * Unability of German and English language use * Anacusis or Hypoacusis with hearing aid device, Amaurosis * Lacking willingness to save and hand out data within the study * Accommodation in an institution due to an official or judicial order * Coworker of the clinic (study center)

Design outcomes

Primary

Measure	Time frame	Description
Postoperative Delirium	Participants will be followed in the sample period, an exspected average of three days	Postoperative Delirium (measured by Nursing Delirium Screening Scale)

Secondary

Measure	Time frame	Description
Concomitant medication	Participants will be followed in the three postoperative days sample period	Concomitant medications from Anticholinergic Drug Scale (ADS)
Postoperative Pain	Participants will be followed in the three postoperative days sample period	According to Numeric Rating Scale
Duration of Intensive Care Unit Stay	Participants will be followed in the sample period, an exspected average of seven days	—
Duration of Hospital Stay	Participants will be followed in the sample period, an exspected average of four weeks	—
Duration of Mechanical Ventilation	Participants will be followed in the sample period, an exspected average of 168 hours	—
Organ Dysfunctions	Participants will be followed in the sample period, an exspected average of three days	—
Hospital Treatment Data	Participations will be followed for the duration of the operation day, an exspected time average of eight hours	Operation time, surgery, anaesthesia
Postoperative Mortality	Participants will be followed for the duration of the sample period an exspected average of five years	Mortality (measured inhouse-mortality according to the patients´records and based on the data record according to §21 Krankenhausentgeltgesetz - (KHEntgG))
Postoperative Delirium	Participants will be followed in the sample period, an exspected average of five years	Postoperative Delirium (measured by Diagnosis of Delirium according to the patients´records and based on the data record according to §21 Krankenhausentgeltgesetz -(KHEntgG))
Comorbidities	Participants will be followed in the sample period, an exspected average of five years	Comorbidities based on the data record according to §21 Krankenhausentgeltgesetz - (KHEntgG)
Readmission rate	Participants will be followed in the sample period, an exspected average of four weeks	—

Countries

Germany

Outcome results