Obesity, Overweight
Conditions
Keywords
intermittent fasting, obesity, calorie restriction
Brief summary
The purpose of Intermittent Fasting study is to investigate whether intermittent fasting could decrease the chronic inflammation levels in overweight/obese people.
Detailed description
The primary objective of this study is to determine whether or not IF reduces the level of chronic inflammation as evidenced by a decrease in high sensitive C-reactive protein (hsCRP), as the main outcome measure
Interventions
OTHERIntermittent Fasting group
Intermittent fasting for 12 months
OTHERcontrol group
usual diet for 6 months and intermittent fasting for other 6 months
Sponsors
Washington University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* The participants in this study will be 50 men and women in the 30 to 65 year age range, who have a BMI in the high normal to moderately obese range (i.e. 24 to 35 kg/m2), * Participants who are eating usual US diets and are sedentary to moderately active (i.e. not exercise trained).
Exclusion criteria
* History of any chronic disease process that could interfere with interpretation of results * Smoking, pregnancy, alcoholism, psychiatric problems, life situations that would interfere with study participation and compliance.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in HSCRP ( high sensitivity C-reactive protein) at 6 and 12 months | Every 6 months- baseline, 6 month and 12 month | HSCRP would be measured in mg/L |
Countries
United States
Outcome results
None listed