Anesthesia, Diabetes, Stress
Conditions
Keywords
diabetic, laparoscopic gastric bypass surgery, stress response, anesthesia, dexmedetomidine
Brief summary
General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Explore the effect of three kinds of anesthesia,that is the total intravenous anesthesia, inhalation anesthesia and inhalation and intravenous anesthesia on stress reactions generated by patients with diabetes conducted gastric - bypass surgery , and choose a best way from three kinds of anesthesia to control stress reaction of diabetics. After selecting the appropriate anesthesia method, assess the effect of dexmedetomidine on controlling stress response from diabetics undergoing laparoscopic gastric-bypass surgical.
Detailed description
Research content and indicators 1. Preparation of serum: 3ml of blood were taken before induction of anesthesia (after entering the operating room), surgery began 1h, surgery began 2h, 24h after surgery, and placed at dry tube, centrifuged for 10min at 3000g after placing at room temperature for 2h , the resulting supernatant was subpassaged in tube, stored at -20℃ until analysis. 2. Indicators to detect in serum contained Tumor Necrosis Factor-α, Interleukin-6, Interleukin-10, plasma glucose, cortisol,insulin and c-peptide. 3. Record the vital signs.
Interventions
OTHERdifferent types of anesthesia
DRUGDexmedetomidine
After selecting the appropriate anesthesia method, assess the effect of dexmedetomidine on controlling stress response from diabetics undergoing laparoscopic gastric-bypass surgical.The stress indicators are the same as described above.
Sponsors
Guangzhou General Hospital of Guangzhou Military Command
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists（ASA）Ⅰ \ Ⅱpatients * Type 2 Diabetes Mellitus patient undergoing Laparoscopic Gastric Bypass surgery * between 18 and 60 years of age
Exclusion criteria
* A history of cardiopulmonary disease, liver and kidney dysfunction, abnormal coagulation * Thyroid disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stress Indicators | 72 hours | We use different anesthesia method to assess the stress indicators,aiming to choose an apposite anesthesia to reduce stress response in laparoscopic gastric bypass for type 2 diabetes mellitus.The stress indicators include Tumor Necrosis Factor-α,Interleukin-10,Interleukin-6,C-peptide,Cortisol,Insulin and Adrenocorticotropic hormone. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vital Signs | during surgery | We record blood pressure, heart rate, end-tidal carbon dioxide,mean arterial pressure at the time of intubation and 45min,90min when the surgery start. |
Countries
China
Contacts
Primary ContactQie wen bin, Master
Outcome results
None listed