Hypertension
Conditions
Brief summary
The study aimed to evaluate the chronic effects of resistance training on blood pressure and biochemical exams in hypertensive elderlies and the influence of the polymorphism of the angiotensin converting enzyme in these response.
Detailed description
To investigate the chronic effects of resistance training on blood pressure and biochemical exams in elderly, 135 hypertensive elderlies were divided into 2 groups: trained and control. The trained group was submitted to a resistance training period. Before the 16 weeks ACE gene was genotyped (PCR). Before and after 16 weeks, blood pressure (ambulatory), HDL-cholesterol, Total cholesterol, Glycemia, Triacylglycerol (colorimetric assay) and plasminogen activator inhibition (PAI-1), intercellular adhesion molecule (ICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), Adiponectin, tumor necrosis factor alpha (TNF-alpha), C Reactive Protein, Angiotensin II, Angiotensin Converting Enzyme, Angiotensin 1-7, (ELISA assay) were measured.
Interventions
BEHAVIORALResistance training
Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR).
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Federal University of São Paulo
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Hypertensives * Age 60 to 85 years * Nonactive
Exclusion criteria
* Orthopedic problems or other problem that prevented the exercises * Change in drug treatment during protocol * Absence in more than 25% of the exercise sessions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure | 16 weeks | Blood pressure was measured by Ambulatorial Monitoring Blood Pressure before and after 16 weeks of intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| VCAM-1 | 16 weeks | VCAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention. |
| HDL-cholesterol | 16 weeks | HDL-cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention. |
| Total Cholesterol | 16 weeks | Total cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention. |
| Glycemia | 16 weeks | Glycemia was analyzed by colorimetric assay, before and after 16 weeks of intervention. |
| Triacylglycerol | 16 weeks | Triacylglycerol was analyzed by colorimetric assay, before and after 16 weeks of intervention. |
| PAI-1 | 16 weeks | PAI-1 was analyzed by ELISA assay, before and after 16 weeks of intervention. |
| ICAM-1 | 16 weeks | ICAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention. |
| TNF alpha | 16 weeks | TNF alpha was analyzed by ELISA assay, before and after 16 weeks of intervention. |
| C Reactive Protein | 16 weeks | C Reactive Protein was analyzed by ELISA assay, before and after 16 weeks of intervention. |
| Angiotensin II | 16 weeks | Angiotensin II was analyzed by ELISA assay, before and after 16 weeks of intervention. |
| Angiotensin Converting Enzyme | 16 weeks | Angiotensin Converting Enzyme was analyzed by ELISA assay, before and after 16 weeks of intervention. |
| Angiotensin 1-7 | 16 weeks | Angiotensin 1-7 was analyzed by ELISA assay, before and after 16 weeks of intervention. |
| Adiponectin | 16 weeks | Adiponectin was analyzed by ELISA assay, before and after 16 weeks of intervention. |
Countries
Brazil
Outcome results
None listed