Cardiovascular Disease, Chronic Disease, Diabetes Mellitus
Conditions
Keywords
Prescription synchronization, Cardiovascular disease, Medication adherence, Randomized controlled trial, Chronic disease, Pharmacy benefit design, Quality improvement
Brief summary
The aim of this study is to evaluate if synchronizing when patients with diabetes and/or coronary artery disease fill their prescriptions improves long-term adherence to these medications.
Interventions
BEHAVIORALPrescription synchronization
Each patient's medication that has the greatest quantity of pills on hand after randomization will be defined as the index medication and partial supplies will be provided for all other eligible medications in order to synchronize all of a patient's medication. Prescribers will be contacted for a new prescription to ensure all eligible medications are on the same renewal schedule. Randomization will occur within strata of whether patients are enrolled in the ReadyFill@Mail program. Once synchronized, patients who are not enrolled in the ReadyFill@Mail program will initiate their own refills. Patients who are enrolled in the ReadyFill@Mail program will have their refills automatically filled, however patients may disenroll from ReadyFill@Mail at any time, in which case they will initiate their own refills. Patients may disenroll in whole or in part from the program at any point.
Sponsors
CVS Caremark
Brigham and Women's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
We will enroll patients 18 years of age and older who within 6 months of study enrollment have filled ≥ 2 medications intended for long-term use (i.e. maintenance medications) by mail order at CVS Caremark. At least 1 of these 2 medications of must be for the treatment of diabetes or cardiovascular disease. In addition, these medications must be delivered on two or more unique delivery dates, there must be at least one refill remaining for all eligible medications and either all or none of their prescriptions must be enrolled in the ReadyFill@Mail program (see Intervention Description for details).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Medication adherence | 12 months | Average adherence to medications for the treatment of cardiovascular disease and diabetes medications as assessed using administrative pharmacy claims |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Full adherence to medications for the treatment of diabetes or cardiovascular disease | 12 months | Percent of subjects achieving full adherence (defined as a Medication Possession Ratio \> 80%) to medications for cardiovascular disease and diabetes |
Other
| Measure | Time frame | Description |
|---|---|---|
| Rates of de-synchronization | 12 months | Rate at which members whose prescriptions have been synchronized elect to discontinue with the synchronization during the study period |
Countries
United States
Outcome results
None listed