Insulin Resistance, Metabolic Syndrome, Obesity
Conditions
Keywords
Physical activity, Exercise, Insulin resistance, High intensity interval training, Fat oxidation, Fitness, Lipids, Blood pressure
Brief summary
A number of studies have shown that short duration, high intensity interval training can improve health-related outcomes, such as insulin sensitivity and cardiorespiratory fitness. However, these often use specialized equipment, such as cycle ergometers, which makes it difficult to roll these interventions out for wide-scale use in the general population. This study aims evaluate the effects of a high intensity shuttle running intervention on insulin sensitivity, fitness and related cardiometabolic risk factors in men who are currently inactive. Participants will be randomized into intervention (4 weeks of shuttle running) and control groups. We hypothesize that the shuttle running programme will result in improved insulin sensitivity, fitness and increased fat oxidation at rest compared with the control group.
Interventions
BEHAVIORALExercise
4-week supervised high intensity shuttle running intervention, 3 sessions per week (12 sessions in total)
Sponsors
University of Glasgow
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* male * 18-40 years * undertaking \< 1 hour per week of planned exercise
Exclusion criteria
* BMI \> 35 kg/m2 * Blood pressure \> 160/90 mm Hg (on anti-hypertensive medication) * history of established coronary heart disease * family history of early cardiac death (\<40 years)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | Change from baseline immediately post-intervention (4 weeks after baseline) | Assessed from glucose and insulin concentrations in fasted state and during oral glucose tolerance test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resting substrate utilization | Change from baseline immediately post-intervention (4 weeks after baseline) | Metabolic rate and fat and carbohydrate oxidation estimated via indirect calorimetry |
| Endurance exercise performance | Change from baseline immediately post-intervention (4 weeks after baseline) | Time taken to complete 100 x 10m shuttle runs |
| Sprint exercise performance | Change from baseline immediately post-intervention (4 weeks after baseline) | Time taken to complete 10 x 10m shuttle runs |
| Waist circumference | Change from baseline immediately post-intervention (4 weeks after baseline) | — |
| Percentage body fat | Change from baseline immediately post-intervention (4 weeks after baseline) | — |
| Clustered Cardiometabolic Risk Score | Change from baseline immediately post-intervention (4 weeks after baseline) | Clustered Cardiometabolic Risk Score = -zHDL+zInsulin+zGlucose+zTriglycerides+( zBMI+zWC)/2+(zSBP+zDBP)/2. |
| Body weight | Change from baseline immediately post-intervention (4 weeks after baseline) | — |
Other
| Measure | Time frame | Description |
|---|---|---|
| Objectively measured physical activity | Change from baseline to week 4 of intervention | Time spent sedentary and physically active assessed by accelerometer |
Countries
United Kingdom
Outcome results
None listed