CMR in Patients With Myocarditis

Value of CMR Including T1 Mapping in Patients With Acute Myocarditis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01962584

Enrollment

Registered

2013-10-14

Start date

2013-09-30

Completion date

2014-10-31

Last updated

2015-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Suspected Acute Myocarditis

Brief summary

To evaluate the additive values of T1 mapping in patients with acute myocarditis.

Detailed description

Cardiac magnetic resonance (CMR) is an established non-invasive diagnostic tool for acute and chronic myocarditis. Established CMR criteria for diagnosing myocarditis are edema on black-blood T2-weighted imaging, relative contrast enhancement seen on T1-weighted imaging for assessment of hyperemia, and late contrast-agent enhancement seen with inversion recovery late enhancement technique for visualization of myocardial fibrosis. Recently, tissue characterization based on calculation of myocardial T1 relaxation time (T1 mapping) as well as T1-derived extracellular volume fraction has become available. Recently, reference values for myocardial T1 relaxation times at 3T for healthy volunteers were published for CMR. However, to date no comprehensive data for multiparametric CMR in patients with suspected myocarditis at 3 Tesla is available. Therefore, the purpose of this prospective study was to evaluate the diagnostic value of CMR at 3T in patients with suspected acute myocarditis using a multiparametric CMR approach including T1 mapping as novel tool for tissue characterization. CMR will be performed within 7 days after hospital admission for suspected acute myocarditis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* patients with suspected acute myocarditis and otherwise unremarkable cardiac history

Exclusion criteria

* exclusion of CAD in invasive coronary angiography * pregnancy * contraindications for MR imaging

Design outcomes

Primary

Measure	Time frame	Description
T1 relaxation times	time of CMR, CMR will be performed within 7 days after hospital admission for suspected acute myocardtitis.	quantification of T1 relaxation times

Secondary

Measure	Time frame	Description
Extracellular volume (ECV)	time of CMR, CMR will be performed within 7 days after hospital admission for suspected acute myocardtitis.	calculation of extracellular volume based on T1 relaxation time

Countries

Germany

Outcome results