Hepatitis B, Liver Fibrosis
Conditions
Keywords
Fibrosis, Liver Cirrhosis, non-invasive, biopsy, hepatitis B virus
Brief summary
The aim of our prospective study is to construct and validate a non-invasive model consisting biochemical markers, FibroScan, and radiological parameters for evaluating liver fibrosis caused by hepatitis B virus in mainland China.
Detailed description
Up to Oct, 2015,total of 1800 patients with chronic HBV infection were enrolled. Paired blood and liver biopsy samples were collected. Blood samples stored at -80 degree Celsius. Liver biopsy samples were judged by three pathology experts.
Interventions
None listed
Sponsors
Peking University First Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. HBsAg positive for at least 6 months 2. agree to have liver biopsy 3. Male or female aged 18 to 65 years old
Exclusion criteria
1. Patients with alcoholic liver disease, autoimmune liver disease, heretic liver disease, drug induced liver disease,nonalcoholic liver disease or other chronic liver disease 2. platelet count \< 80000/L 3. prothrombin activity ≤ 60% 4. patients with any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the subject
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| determine whether a non-invasive test or a combination of non invasive tests may be used to accurately evaluate liver fibrosis in patients with chronic hepatitis B | singular evaluation at the time of liver biopsy |
Countries
China
Outcome results
None listed