Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU

Conditions

Patients With Acute Renal Insufficiency

Brief summary

After obtaining written informed consent and inclusion, patients will be randomised into 2 groups for the type of dialysis catheter lock: * The first group will have a citrate lock * The second group will have a heparin lock Patients will be stratified according to the centre and type of Renal Replacement Therapy (RRT) continuous or intermittent. The daily surveillance of patients will not be different from the usual surveillance of patients on Renal Replacement Therapy. The hemodialysis catheters used will be specific Renal Replacement Therapy catheters. The decision to withdraw the catheter will be made by the investigator and based on clinical criteria (complications related to the catheter, termination of Renal Replacement Therapy…)

Quenot JP, Helms J, Bourredjem A, Dargent A, Meziani F, Badie J, Blasco G, Piton G, Capellier G, Mezher C, Rebibou JM, Nadji A, Crepin T, Barbar SD, Fleck C, Cransac A, Boulin M, Binquet C, Soudry-Faure A, Bruyère R, VERROU-REA Trial Investigators and the CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis).

2019-07-0121 citations

10.1186/s13613-019-0553-4

Comparison of heparin to citrate as a catheter locking solution for non-tunneled central venous hemodialysis catheters in patients requiring renal replacement therapy for acute renal failure (VERROU-REA study): study protocol for a randomized controlled trial

Rémi Bruyère, Agnès Soudry‐Faure, Gilles Capellier, Christine Binquet, Abdelouaïd Nadji et al. (10 authors)

Trials2014-11-1911 citations

10.1186/1745-6215-15-449

Interventions

DRUGCitrate 4%

DRUGunfractionated heparin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Patients aged \> 18 years * Requiring RRT for acute renal insufficiency * For which a 1st non-tunneled catheter is placed * In the jugular or femoral position * After written informed consent has been obtained from the patient, a member of the family or a person of trust

Exclusion criteria

* Patient presenting active poorly controlled bleeding * Known allergy to citrate * Acute liver failure (Prothrombin level \<30%) * Thrombopenia \< 30 000/mm3 * Known or suspected heparin-induced thrombopenia * Known systemic bacterial infection at the time the catheter is placed * catheter in the subclavicular position * Persons not affiliated to a national health insurance scheme * Pregnant women * Adults under guardianship

Design outcomes

Primary

Measure	Time frame
Duration of event-free survival of the first non-tunneled hemodialysis catheter (defined at the time in days from catheter insertion to withdrawal whatever the reason)	up to 28 days

Countries

France

Outcome results

None listed