Hip Fractures, Perioperative Myocardial Ischemia
Conditions
Keywords
Continuous lumbar plexus (LP) block analgesia
Brief summary
The purpose of this study is evaluate the efficacy of perioperative continuous lumbar plexus block in reducing the risk of cardiac ischemic events of elderly patients undergoing surgery for hip fractures, expressed as a reduction of ischemic events per subject.
Interventions
PROCEDUREContinuous lumbar plexus (LP) block analgesia
Sponsors
Pontificia Universidad Catolica de Chile
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with hip fracture within 48 hours of evolution * Known coronary artery disease: Previous myocardial infarction Chronic stable angina Atypical angina with positive exercise test for coronary flow failure. Evidence of coronary artery disease with ultrasound, scintigraphic or angiographic compatible * Patients with at least two of the risk factors for coronary heart disease as defined by Wallace (1998)
Exclusion criteria
* Patients receiving orthopedic treatment. * Patients with coagulopathy, clinic or laboratory. * Patients with sepsis or infection of the catheter insertion site of lumbar plexus. * Patients with neurological diseases evolving. * Patients disoriented, or dementia. * CKD stage IV National Kidney Foundation (2) * Glomerular filtration rate between 15 and 29 mL/min/1, 73 m2 * Patients unable to use the Numeric Rating Scale (NRS) to assess pain. * Patients with non-sinus rhythm or conduction abnormalities (right bundle branch block or left, atrioventricular block) in the admission ECG * Patients with pacemaker. * Enrolled patients with acute coronary syndrome or decompensated cardiovascular disease at entry. * Allergy to any of the drugs of the protocol. * Inability to understand or unaided sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluate the efficacy of perioperative continuous lumbar plexus block in reducing the risk of cardiac ischemic events of elderly patients undergoing surgery for hip fractures, expressed as a reduction of ischemic events per subject. | 3 days |
Secondary
| Measure | Time frame |
|---|---|
| Major cardiovascular events (myocardial infarction, acute pulmonary edema, arrhythmias). | 3 days |
| hospital death | 3 days |
| Death at 30, 90 and 360 days after surgery | 1 year |
| Perioperative Pain Intensity, measured in numerical rating scale (NRS). | 3 days |
| Evaluate Adverse events (hypotension, respiratory depression, systemic toxicity, etc..) | 3 days |
Countries
Chile
Outcome results
None listed