Healthy
Conditions
Keywords
dietary nitrate, beetroot juice, exercise performance, oxygen consumption
Brief summary
It was shown by some researchers that dietary nitrate such as beet root juice can lower oxygen consumption in men and act as a performance enhancing supplement. It was not shown, what the optimal dosage is and if there is any difference in oxygen consumption comparing beet root juice and inorganic nitrate. Therefore, the aim of the study is to conduct a study ingesting different sodium nitrate and beet root juice dosages. We would measure nitrate and nitrite concentrations in the blood at different time points and the subjects have to perform an exercise test measuring oxygen consumption 3 hours after the ingestion of nitrate.
Detailed description
1. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Every hour a blood withdrawal is taken to measure nitrate and nitrite concentration in the blood. 2. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Three hours after the intake of the supplement the subjects have to perform an exercise test on a bicycle. They have to cycle 5 min at 50% of maximal oxygen consumption and 8min at 80% of maximal oxygen consumption separated by a 5min break. Oxygen consumption would be measured during the whole exercise test. Blood withdrawal is taken before the ingestion, after 3 hours and after the test.
Interventions
DIETARY_SUPPLEMENTsodium nitrate
Ingestion of 3mmol, 6mmol and 12mmol sodium nitrate
DIETARY_SUPPLEMENTBeetroot juice
concentrated beetroot juice (dosage 3mmol, 6mmol and 12mmol)
Sponsors
University of Zurich
Swiss Paraplegic Research, Nottwil
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18 to 45 * healthy active men * non-smoking
Exclusion criteria
* medication intake during study phase
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| oxygen consumption | 30min | Oxygen consumption during exercise protocol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | 6 hours | every hour, blood pressure is measured. |
| oxygen saturation | 6 hours | every hour oxygen saturation is measured. |
| Rating of perceived exertion (RPE) | during the 7 weeks of study phase | RPE is measured after the low-intensity exercise performance and after the submaximal exercise performance. |
| Heart rate | during the 7 weeks of study phase | Heart rate is measured before the ingestion, before the exercise test and during the exercise test. resting heart rate is additionally measured every hours after the intake of dietary/inorganic nitrate. |
| Nitrate and nitrite concentration | 6 hours | every hour for the six hours after the ingestion of dietary/inorganic nitrate, nitrate and nitrite concentration in the blood is analyzed. |
Countries
Switzerland
Outcome results
None listed