Postprandial VLDL-TG Metabolism

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01961024

Enrollment

Registered

2013-10-11

Start date

2014-01-31

Completion date

2015-08-31

Last updated

2017-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes

Keywords

VLDL-TG kinetics, Postprandial state, Obesity

Brief summary

In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

MALE

Age

30 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Written consent

Exclusion criteria

* Known diseases * Alcohol abuse * Smoker * Regular use of medicine

Design outcomes

Primary

Measure	Time frame
VLDL-TG storage in adipose tissue	3 hours

Secondary

Measure	Time frame
18F-THA fractional storage	6 Hours

Countries

Denmark

Outcome results