Comparative Bioavailability
Conditions
Keywords
Fish Oil, EPA, DHA, Omega-Score, Lipemic Index, ethyl esters, triglycerides, phospholipids
Brief summary
Supplementation with omega-3 fatty acids has been extensively researched and is known to provide healthful benefits for patients with a diversity of conditions and diseases. Not all omega-3 supplements are created equally however; some sources of omega-3 fatty acids are superior to others due to a greater bioavailability of omega-3 fatty acids than others, differences in source material, and processing techniques. The purpose of this study is to determine which marketed omega-3 product provided the greatest effect, as measured against its' label claim and recommended dosage.
Interventions
DIETARY_SUPPLEMENTOmega-3 Fatty Acids
Sponsors
Nutrasource Pharmaceutical and Nutraceutical Services, Inc.
Nordic Pharma, USA
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participant is fluent in English * Participant understands the study requirements and is willing to comply with the protocol * Participant is willing to provide written informed consent * Participant is 18 years of age or older
Exclusion criteria
* Unwilling or unable to provide written consent * Participant has taken omega-3 supplements in the last 3 months * Participants consumes fish on a regular basis (more than 1 serving per week) * Females who are pregnant or breastfeeding * Participant has an allergy to fish or seafood * Participant has been diagnosed with any medical illness or conditions * Participant has a history of drug dependence or substance abuse (excluding nicotine) * Participant is taking cholesterol or triglyceride lowering medications or supplements (statins, niacin, carnitine, fibrates) * Individual has difficulty giving multiple blood samples
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Omega-Score | Change from Baseline in Omega-Score at 28 days | The Omega ScoreTM is a measurement of the levels of the Omega-3 Fatty Acids in a blood sample. The summed amounts of these Omega-3 Fatty Acids (EPA+DPA+DHA) as a % of the total fatty acids represents the Omega ScoreTM in whole blood. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lipemic IndexTM | Change from Baseline in Lipemic Index at 28 days | The Lipemic Index™ is the post-prandial rise in TG levels over a 5-hour period, following the consumption drink containing a measured amount of fat, carbohydrate and protein. |
Countries
Canada
Outcome results
None listed