Colorectal Cancer Metastatic
Conditions
Keywords
Advanced colorectal cancer of liver metastatic
Brief summary
To evaluate the efficacy and safety of Raltitrexed for advanced colorectal cancer
Detailed description
evaluate the efficacy and safety of Raltitrexed and oxaliplatin and lipiodol transcatheter arthrial chemoembolization for in refractory colorectal carcinoma with liver metastases.
Interventions
DRUGRaltitrexed
4mg, every 4 weeks,transhepatic arterial infusion
DRUGOxaliplatin
100\ 150mg, every 4 weeks, transhepatic arterial infusion
DRUGlipiodol
5-20ml, every 4 weeks, hepatic artery embolization
Sponsors
Nanjing Chia-tai Tianqing Pharmaceutical
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Histologically confirmed colorectal adenocarcinoma 2. Disease limited to the liver Unresectable disease by surgery or other local therapies 3. Age \>18 years 4. ECOG performance status 0-2,Child pugh A or B 5. Expected survival ≥ 3 months 6. Adequate hematological, hepatic, and renal function
Exclusion criteria
1. Pregnant or lactating women 2. Patients with severe organ dysfunction or failure 3. With severe cardiovascular disease, or mental 4. Extraliver metastases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progression-free survivial | 8 months after last patient randomized | From date of randomization until date of first documented PD, date of death |
Countries
China
Contacts
Primary ContactJianhua Wang
Outcome results
None listed