Dementia
Conditions
Keywords
dementia, drumming, emotion, cognition, functional MRI
Brief summary
The purpose of this study is to determine if the effects of music therapy alter emotion and cognition performances of individuals with mild to moderate dementia. The music therapy intervention protocol is structured by drum improvisation, rhythm imitation, music cognition and song discussion. Attentive listening and active participation of the music training activities allow participants to utilize their focus of attention and comprehension of informational texts. Music therapy intervention is proposed to provide positive stimulations on emotion and cognitive functions of individuals with dementia. The results of the present study will clarify relationship between the effect of music therapy and the neural substrate of music therapy in anatomical and functional brain data obtained from MRI (fMRI).
Detailed description
Individuals with dementia often exhibit deterioration in cognitive functions and experience changes in emotions and personalities. Due to the changes in the frontal and temporal lobes of the brain, individuals with dementia often experience an impaired ability to judge situations. Empirical studies have indicated that cognitive stimulation is essential to facilitate individuals with dementia in thinking, concentration, and memory. Structured music activities provide cognitive stimulation to individuals with dementia through attentive listening and active participation. Additionally, drum improvisation not only reflects the current status of an individual, but also serves as an audio feedback through free play.
Interventions
BEHAVIORALMusic Therapy Group Session
Sponsors
Chang Gung Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
55 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* a mild dementia diagnosis with Clinical Dementia Rating (CDR) score: 1 and The Mini Mental State Examination (MMSE) score: 18-24
Exclusion criteria
* significant visual and hearing impairment that hinders music listening and score reading * for fMRI safty: with shrapnel or other metal or electronic implants in their bodies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain Changes from Baseline on Functional and Structural Connectivity at 2 Months by Multi-Model MRI Analyses | Baseline and after 8-week music therapy intervention | All participants will received two MRI scans at 0 and 2 months. Images will be acquired on a 3.0T Siemens MRI scanner with 12-channels head coil. All the images are acquired parallel to the anterior commissure-posterior commissure line. To minimize motion artifact generated during the image acquisition, each participant's head will be immobilized with cushions inside the coil. Three kinds of MRI techniques will be performed in this study, including T1-weighted high-resolution anatomical image, resting-state function MRI, and half-sphere diffusion spectrum imaging. Therefore, T1VBM(voxel-based morphology), TBSS(tract-based spatial statistics), functional brain network analysis, and structural brain network analysis will be employed for evaluating the changes of brain functional and structural connectivity in individuals with dementia in experimental and control groups. |
Secondary
| Measure | Time frame |
|---|---|
| Change from Baseline on Frontal Assessment Battery (FAB) at 2 Months | Baseline and at 2 Months |
| Change from Baseline on Quality of Drum Improvisation at 2 Months | Baseline and at 2 Months |
| Change from Baseline on Geriatric Depression Scale (GDS) at 2 Months | Baseline and at 2 Months |
| Change from Baseline on Cohen-Mansfield Agitation Inventory (CMAI) at 2 Months | Baseline and at 2 Months |
| Change from Baseline on Inventory of Quality of Life (SF-36) at 2 Months | Baseline and at 2 Months |
Countries
Taiwan
Contacts
Primary ContactYu-Cheng Pei, PhD
Backup ContactYen-Hsuan Yang, PhD
Outcome results
None listed