Correlation Between NAFLD, Epicardial Adipose Tissue and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01958411

Enrollment

340

Registered

2013-10-09

Start date

2008-12-31

Completion date

Unknown

Last updated

2013-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis, Non-alcoholic Fatty Liver Disease

Brief summary

* Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques. * Non-alcoholic fatty liver disease (NAFLD) is closely associated with many cardiometabolic risk factors. NAFLD can be detected by measuring liver fat accumulation using computed tomography (CT). * Also epicardial adipose tissue (EAT) volume as determined by computed tomography (CT) is an independent marker of cardiovascular events in the general population. * Therefore, the purpose of this investigators study is to compare the NAFLD severity and EAT volume with FDG uptake measured by PET/CT.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy patients for visiting routine medical check in our clinic

Exclusion criteria

* History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization) * Diabetes * Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg) * Malignancy * Severe renal or hepatic disease * Subjects taking medications that might affect inflammation such as nonsteroidal antiinflammatory drug and statin

Design outcomes

Primary

Measure	Time frame
Correlation between vascular inflammatory status measured by 18FDG PET and NAFLD measured by un-enhanced CT	12 weeks
Correlation between vascular inflammatory status measured by 18FDG PET and epicardial adipose tissue measured by CT	12 weeks

Secondary

Measure	Time frame
The relationship of NAFLD with carotid intima media thickness	12 weeks
The relationship of epicardial adipose tissue volume with carotid intima media thickness	12 weeks

Countries

South Korea

Outcome results