Occlusion of Bile Duct With an External Bile Diversion.
Conditions
Keywords
TICE-human-stable isotopes
Brief summary
So far, the liver has been the main target for cholesterol elimination. However, several recent studies performed in mice have described a new route of cholesterol excretion, the Trans-Intestinal Cholesterol Excretion or TICE. TICE allows direct elimination of plasma cholesterol in the feces directly via the intestine. Until now, only indirect evidence suggests that TICE is also active in humans, the goal of this proof of concept study is to provide the first proof of its existence in humans by using stable isotopes in patients with bile duct diversion.
Interventions
OTHERIntravenous injection of deuterated cholesterol diluted in intralipid 20%
At day 0, bile diverted patients will receive an intravenous injection of deuterated cholesterol diluted in intralipid 20%. The plasma, biliary and fecal content of deuterated cholesterol will be measured, by mass spectrometry, at 24, 48 and 72 hours after the initial input.
Sponsors
Nantes University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- External bile duct diverted patients
Exclusion criteria
* Inflammatory bowel disease * Aphagia * Renal or hepatocellular insufficiency * Primary intestinal tumor * Cholangitis or severe sepsis * Acute or chronic diarrhea
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measuring trans-intestinal cholesterol excretion in vivo in bile diverted patients | Day 3 | Measuring trans-intestinal cholesterol excretion in vivo in bile diverted patients |
Countries
France
Contacts
Primary ContactBertrand CARIOU, Professor
Backup ContactCedric LE MAY, Doctor
Outcome results
None listed