Mean Systemic Pressure Measurement During Prone Position Surgery

Study of Hemodynamic Variations During Prone Position Surgery: Measurement of Mean Systemic Pressure and Venous Return Resistance

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01957605

Enrollment

Registered

2013-10-08

Start date

2013-12-31

Completion date

2016-10-31

Last updated

2015-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic Variation During Surgery

Keywords

prone position, hemodynamic variation, mean systemic pressure

Brief summary

Venous return is driven by the pressure gradient between mean systemic pressure and right atrial pressure. However, mean systemic pressure is more a physiological concept than an available clinical measurement. Indeed, the mean systemic pressure is the one that would be measured anywhere within the vascular system after cardiac arrest. Recent advances in hemodynamic monitoring have made MSP available to the clinician through beat-by-beat cardiac output measurements during respiratory pauses under mechanical ventilation. In this way, it is possible to calculate MSP, the pressure gradient and the venous return resistances. The investigators aim is to explain the hemodynamic variations and the decrease in cardiac output observed during prone position. The investigators hypothesis is that venous return resistances are increased during prone position probably following an increased intra-abdominal pressure.

Interventions

None listed

Study design

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Prone position neurosurgery * High-risk neurosurgery

Exclusion criteria

* Emergency surgery * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
mean systemic pressure variation	during surgery after the patient is put in prone position	change of mean systemic pressure from supine position to prone position during surgery

Secondary

Measure	Time frame	Description
intrathoracic pressure variation	during surgery during surgery after the patient is put in prone position	Change of intrathoracic pressure from supine position to prone position during surgery
intravesical pressure variation	during surgery during surgery after the patient is put in prone position	Change of intravesical pressure from supine position to prone position during surgery

Countries

France

Contacts

Primary ContactJulien Pottecher, MD

julien.pottecher@chru-strasbourg.fr+33(0)3 88 12 70 95

Outcome results