Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01957293

Acronym

Salmon-Basel

Enrollment

Registered

2013-10-08

Start date

2013-10-31

Completion date

2014-02-28

Last updated

2014-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Memory Functions

Brief summary

Aim is to investigate the effect of beta2 adrenergic stimulant salbutamol on emotional and cognitive functions in healthy humans.

Interventions

DRUGSalbutamol

single oral administration, 4 mg

DRUGPlacebo

single oral administration

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy, male and female, aged between 18 and 40, BMI be-tween 19 and 27 kg/m2, normotensive (BP between 90/60 mmHg and 140/90 mmHg), native or fluent German-speaking, caucasian (European ancestry), able and willing to give written informed consent and comply with the requirements of the study protocol, willing to donate saliva sample for DNA-analysis -

Exclusion criteria

Acute or chronic psychiatric or somatic disorder, tachycardia at rest (\> 100 bpm), known hypersensitivity to salbutamol, pathological ECG, pregnancy, breast-feeding, long-term medication within last 3 months (oral contraceptives are disregarded) smoking (\>3 cigarettes per day), concurrent participation in another study, participation in one of our previous studies using the same memory tests, inability to read and understand the participant's information. -

Design outcomes

Primary

Measure	Time frame	Description
Change of emotional memory functions under Salbutamol	two testing days within 10 days	memory tests
Change of episodic memory functions under Salbutamol	two testing days within10 days	memory tests

Secondary

Measure	Time frame	Description
Change of emotional state under salbutamol	Two testing days within 10 days	questionnaires
change of attention functions under salbutamol	two testing days within 10 days	attention tests

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026