Insulin Resistance
Conditions
Keywords
L-arabinose, D-xylose, sucrose, glucose, insulin, C-peptide, GLP-1
Brief summary
The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.
Detailed description
Based on previous scientific results we hypotesize, that pentoses decreases the demand for insulin in metabolizing a given dose of sucrose.
Interventions
DIETARY_SUPPLEMENTPlacebo comparator: 0% pentose
14 healthy subjects participated in a randomized double-blinded cross-over study based on four single tests. Sucrose containing drinks were supplemented with two different doses of D-xylose and in addition one dose of L-arabinose was included for comparison with earlier studies. Blood was collected fasting and for 3-h postprandially. Appetite sensations and energy intake were registered. Gastrointestinal symptoms were monitored for 24 hours
DIETARY_SUPPLEMENTActive comparator: 4% D-xylose
DIETARY_SUPPLEMENTActive comparator: 8% D-xylose
DIETARY_SUPPLEMENTActive comparator: 8% L-arabinose
Sponsors
Danisco
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy males * BMI between 18.4-25 kg/m2 * age between 18 and 30
Exclusion criteria
* donation of blood 3 months before or during the study * gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease (HIV or hepatitis) * smoking * consumption of more than 21 alcoholic drinks/week * elite athletes * on medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood glucose, insulin, C-peptide and GLP-1 | -15, 0, 15, 30, 45, 60, 90, 120, 180 min | Level of glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) over time, the area under the curve (AUC), the peak value and time to peak |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Appetite measurements and energy intake | -15, 30, 60, 90, 120, 150 and 180 min | Appetite measurements: area under/over the curve (AUC/AOC), 3-h mean. Energy intake: the ad libitum energy intake at lunch was registered. VAS was used to asses the palatability (appearance, smell, taste, after-taste and overall palatability) of the ad libitum lunch. |
Countries
Denmark
Outcome results
None listed