Long Term Results of the Use of Oxybutynin for the Treatment of Hyperhidrosis

Retrospective Evaluation of Long Term Use of Oxybutynin in the Pharmacological Treatment of Primary Hyperhidrosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01956591

Enrollment

1100

Registered

2013-10-08

Start date

2007-09-30

Completion date

2013-09-30

Last updated

2013-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperhidrosis

Keywords

Treatment efficacy, Long-term effects, Tachyphylaxis, Undesirable effects, Side effects, Self-assessment, Hyperhidrosis, Quality of life

Brief summary

Evaluate the long term efficacy and side effects of oxybutynin in the treatment of hyperhidrosis.

Detailed description

This retrospective study aims to evaluate the medical charts of patients who were treated with oxybutynin for at least six months for primary hyperhidrosis. The investigators variables of interest are: (1) quality of life before pharmacological therapy and after six weeks, (2)self-perception of improvement in hyperhidrosis after six weeks of treatment and on last visit (whenever this occur, as long as this happens after six months), (3) side effects related to drug use.

Interventions

DRUGOxybutynin

All patients are treated with oxybutynin for hyperhidrosis. Usual maintenance dose is 10mg/day, but dose may vary according to weight, efficacy and side effects. Our standard protocol starts with 2.5mg/day in the first 7 days, progresses to 5mg/day for 14 days and then reaches the usual maintenance dose of 10mg/day afterwards.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to No maximum

Healthy volunteers

Inclusion criteria

* Primary hyperhidrosis * At least 180 days of treatment with oxybutynin

Exclusion criteria

* Incomplete medical chart * Patients with glaucoma

Design outcomes

Primary

Measure	Time frame	Description
Quality of life	1 day before treatment	Evaluate the Quality of life (using a standardized questionnaire for hyperhidrotic patients) before pharmacological treatment

Secondary

Measure	Time frame	Description
Perception of improvement in excessive sweating	After 42 days of treatment	We want to analyze the patient's self perception (grades 0 to 10) of amelioration in sweating after forty-two days of treatment

Other

Measure	Time frame	Description
Side effects in the use of oxybutynin for hyperhidrosis	After 42 days of treatment	Assess the side effects that have been reported on patient's charts, such as: dry mouth, constipation, headache, glaucoma, bowel obstruction and any other side effect reported

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026