Assess the Variation of Apparent Diffusion Coefficient
Conditions
Keywords
ADC, breast cancer, complete pathological response
Brief summary
The main objective of the study is to assess the sensitivity and the specificity of the variation of apparent diffusion coefficient for prediction, after a course of neoadjuvant chemotherapy or after modification of the treatment sequence, the pathological response at the end of chemotherapy
Interventions
MRI will be realised at the beginning of the study, after a cycle of chemotherapy or at changement of sequence and at the end of chemotherapy.
Sponsors
Centre Jean Perrin
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age\> 18 years. * Patient suffering from a breast tumor, regardless of the stage and size * Patient requiring neoadjuvant chemotherapy * Patient has the ability to undergo 18F-FDG-PET at baseline, at end of cycle 1 and at the end of neoadjuvant treatment before surgery * Compulsory affiliation to a social security system. * Obtaining informed consent in writing, signed and dated.
Exclusion criteria
* Patient with cognitive or psychiatric disorders. * Patient deprived of liberty by a court or administrative. * Patient with signs against the achievement of MRI, mammography and ultrasound * Patient metastatic * Patient with prior chemotherapy, radiotherapy and hormone therapy for her breast cancer * Pregnant women, current lactation * Patient suffering from uncontrolled diabetes (\> 11 mmol / L)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation of apparent diffusion coefficient before / after a cycle of neoadjuvant chemotherapy or before / after modification of the treatment sequence and correlated with histologic response | One year |
Outcome results
None listed