PST Linkage Based Analysis in the Family of More Than Two Members With Type 1 Diabetes in Taiwan

Parent-sibling Tracing (PST) Linkage Based Analysis in the Family of More Than Two Members With Type 1 Diabetes in Taiwan for Novel HLA and Non-HLA Candidate Risk Alleles Detection

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01955746

Acronym

PATT

Enrollment

Registered

2013-10-07

Start date

2013-09-30

Completion date

2014-06-30

Last updated

2014-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Genetic Variation of Type 1 Diabetes

Brief summary

The purpose of this study is to explore the susceptible genes for Type 1 diabetes in Taiwan through the new genetic study methods.

Detailed description

As an unclear autoimmune disorder, the pathogenesis of type 1 diabetes (T1D) remains elusive. Among all the methods for studying diseases pathophysiology, genetic approach has valuable capability as being both hypothesis-testing and hypothesis-generating. Although geo-epidemiological studies show relatively higher prevalence of T1D in Caucasians than in Asians, whether genetic factors identified in T1D of Caucasians are essential for T1D in Asians is not yet clarified. Although the human leukocyte antigen (HLA) genotype variants have been reported to be associated with T1D, the odds ratio (ORs) is relatively low in Taiwan as comparing with western countries, some families are indeed more than one child with T1D. However, the genetic linkage study in T1D is still limited in Taiwan that hampered the drug development or research in T1D. Therefore, we intend to explore the susceptible genes for T1D of Taiwan in this study, which will provide further researcher directions for this disease.

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. Type 1 diabetes on the criteria of the American Diabetes Association with a very low C-peptide level (\<0.35 ng/mL) with or without the experience of diabetic ketoacidosis. 2. The subjects whose four grandparents are of Chinese Han origin

Exclusion criteria

1. Patients with ages of onset more than 35 years are excluded. 2. The families having any member with known possible type 2 diabetes

Design outcomes

Primary

Measure	Time frame
Type 1 diabetes gene	1 year

Countries

Taiwan

Outcome results