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Embryo Implantation After Induced Endometrial Injury

Evaluation of Induced Endometrial Injury in the Subsequent IVF Cycle.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01955356
Enrollment
600
Registered
2013-10-07
Start date
2013-10-31
Completion date
2022-11-21
Last updated
2023-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sterility

Keywords

Scratching, Endometrial biopsy, Ongoing embryo implantation, Assisted reproductive techniques

Brief summary

Some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure. The purpose of this study is to determine whether the induced endometrial injury could be beneficial for regular patients undergoing IVF

Detailed description

Endometrial induced injury has been suggested that could improve embryo implantation in cases of patients with recurrent implantation failure. The mechanisms that induce that improvement remain unknown. We want to analyse if the endometrial induce injury could be useful in cases of standard patients who require assisted reproductive techniques. For that purpose we will start a randomized controlled trial with the ideal background in implantation in ART, the egg donation programme.

Interventions

PROCEDUREScratching

Endometrial biopsy

Sponsors

IVI Madrid
CollaboratorOTHER
IVI Barcelona
CollaboratorOTHER
IVI Murcia
CollaboratorOTHER
Vida Recoletas Sevilla
CollaboratorOTHER
IVI Bilbao
CollaboratorOTHER
IVI Vigo
CollaboratorOTHER
Instituto Valenciano de Infertilidad, IVI Alicante
CollaboratorOTHER
Instituto Valenciano de Infertilidad, IVI VALENCIA
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Age
19 Years to 44 Years
Healthy volunteers
No

Inclusion criteria

* 19-44 aged women * 19-29.9 Kg/m2. * 1st or 2nd fresh embryo transfer ( egg donation). * 1 or 2 blastocysts available. * written agreement. * \> or = 6 mms endometrial thickness.

Exclusion criteria

* Premature ovarian failure. * Endometrial pathology. * Insufficient endometrial development. * Hydrosalpinx * Mullerian malformations.

Design outcomes

Primary

MeasureTime frame
Ongoing implantation rate (OIR)12 weeks of pregnancy

Secondary

MeasureTime frame
Live born rate (LBR)9 months after embryo transfer

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026