Parkinson's Disease
Conditions
Brief summary
The purpose of this study is to assess the impact of different parameters (voltage, pulse width, frequency) of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor symptoms in patients with Parkinson's disease (PD).
Detailed description
In this observational study, we will retrospectively analyze the one-year follow-up data of 27 PD patients who received bilateral STN DBS in the First Affiliated Hospital of Sun Yat-sen University in the years 2008-2012. The data, including parameter settings and severity of motor symptoms indicated by Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores, was collected during the patients' annual visit to the hospital for reprogramming. A correlation analysis will be conducted to investigate the relationship between change of a specific parameter and the subsequent change of motor scores.
Interventions
None listed
Sponsors
First Affiliated Hospital, Sun Yat-Sen University
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* PD patients treated with bilateral STN DBS in the First Affiliated Hospital in the years 2008-2012
Exclusion criteria
* Simultaneous participation in another clinical trial * Dementia (Mini Mental State Examination \< 26) * Removal of DBS electrodes * Loss to follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of parameters (voltage, pulse width, frequency) during follow-up | at 12 months |
| Change of UPDRS Part III score and the relation to parameters | at 12 months |
| Changes of tremor, rigidity, bradykinesia and postural stability scores evaluated by UPDRS Part III and the relation to parameters | at 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Change of daily levodopa equivalent dosage (LED) during follow-up | at 12 months |
Countries
China
Outcome results
None listed