Changes in Spontaneous Ventilation in Response to Changes in Extracorporeal Carbon Dioxide Removal

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01953484

Enrollment

Registered

2013-10-01

Start date

2013-07-31

Completion date

Unknown

Last updated

2013-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Insufficiency

Brief summary

In physiological conditions, spontaneous ventilation is controlled by blood carbon dioxide (and pH) levels. In healthy animals, extracorporeal carbon dioxide removal leads to hypoventilation or apnea (Kolobow et al., 1977). During acute respiratory insufficiency, extracorporeal carbon dioxide removal may be used to control spontaneous ventilation, limiting risks of lung damage and relieving dyspnea (Crotti et al., 2012). However, little is known about how spontaneous ventilation changes in response to changes in extracorporeal carbon dioxide removal during acute respiratory insufficiency, especially in humans. Aim of this study is to monitor changes in spontaneous ventilation in awake patients treated with extracorporeal gas exchange support because of acute respiratory insufficiency, in response to changes in extracorporeal carbon dioxide removal.

Interventions

OTHERChange in extracorporeal carbon dioxide removal

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Acute Respiratory Insufficiency * Extracorporeal gas exchange support * The patient is spontaneously breathing (including assisted ventilation)

Exclusion criteria

\- age below 18 yrs

Design outcomes

Primary

Measure	Time frame	Description
Spontaneous ventilation	30-60 minutes after changing extracorporeal carbon dioxide removal	Extracorporeal carbon dioxide removal will be increased or decreased changing the gas flow to the extracorporeal membrane lung. Actual extracorporeal carbon dioxide removal will be measured. Spontaneous respiratory rate, tidal volume, minute ventilation, esophageal pressure swings and comfort of the patient will be recorded 30-60 minutes after changing extracorporeal carbon dioxide removal.

Countries

Italy

Contacts

Primary ContactLuciano Gattinoni, Prof.

gattinon@policlinico.mi.it+39-02-55033285

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026