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Importance of Peritoneal Free Fluid Cultures in Acute Appendicitis

Importance of Peritoneal Free Fluid Cultures in Both Perforated and Non-perforated Appendicitis

Status
Withdrawn
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT01953289
Acronym
IFFSA
Enrollment
0
Registered
2013-09-30
Start date
2012-07-31
Completion date
2014-12-31
Last updated
2015-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appendicitis

Keywords

Appendicitis, Free fluid

Brief summary

The purpose of this study is to evaluate the frequency of positive free fluid cultures in both perforated and non-perforated appendicitis. In addition predictors of positive free fluid cultures will be analyzed.

Detailed description

Prior to surgery, all patients will receive antibioprophylaxis. In case of free peritoneal fluid, a sample is aspirated and sent for microbiology. A lavage with saline is not necessary. The decision to start postoperative antibiotic is left at the discretion of the surgeon. The decision to leave an abdominal drain is left at the discretion of the surgeon. The use of a preoperative single dose administration of antibiotics has been extensively studied and found beneficial in the prevention of SSI in appendicitis. However, the use of continued postoperative antibiotics has barely been studied. The sparse evidence that exist does not seem to support its systematic use. During appendectomy the surgeon frequently encounters turbid free fluid, even in non-perforated appendicitis. It is common practice in Belgium to continue antibiotic prophylaxis for 5 days after aspiration and lavage. Although the aspect often seems purulent, it is unknown in what percentage this fluid is contaminated. Also, it is unknown whether after aspiration and lavage intra-abdominal drains are necessary.

Interventions

None listed

Sponsors

Universitaire Ziekenhuizen KU Leuven
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
6 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* Appendicitis (Perforated/ Non-perforated) Free fluid Age: 6 - 90y

Exclusion criteria

* Immunosuppression (recent chemotherapy, chronic use of immunosuppressive medication) Age \< 6 and \> 90y

Design outcomes

Primary

MeasureTime frameDescription
To evaluate the frequency of positive free fluid cultures in both perforated and non-perforated appendicitis24 hoursIn case of free peritoneal fluid, a sample will be aspirated and sent for microbiology.

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026