Prevention of Intrathecal Morphine Induced Pruritus: Comparison of Ondansetron and Palonosetron

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01952626

Enrollment

Registered

2013-09-30

Start date

2013-04-30

Completion date

2014-06-30

Last updated

2015-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morphine Adverse Reaction

Keywords

intrathecal, morphine, ondansetron, palonosetron, pruritus

Brief summary

Intrathecal administration of morphine is often used for control of postoperative pain. However, pruritus is one of the most common side effects of intrathecal morphine . Specific serotonin receptor antagonists could be an effective prophylactic treatment of neuraxial opioid-induced pruritus. It was reported that palonosetron is more effective than ondansetron for prevention of postoperative nausea and vomiting. Therefore, the investigators evaluated the efficacy of prophylactic administration of ondansetron and palonosetron for the prevention of intrathecal morphine-induced pruritus.

Detailed description

Intrathecal administration of morphine is often used for relief of postoperative pain. However, pruritus is one of the most common side effects associated with intrathecal morphine. Specific serotonin receptor antagonists such as ondansetron could be an effective prophylactic treatment of neuraxial opioid-induced pruritus. It was reported that palonosetron is more effective than ondansetron for prevention of postoperative nausea and vomiting. Therefore, the investigators evaluated the efficacy of prophylactic administration of ondansetron and palonosetron for the prevention of intrathecal morphine-induced pruritus.

Interventions

DRUGOndansetron

intravenous injection

DRUGPalonosetron

intravenous injection

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to 70 Years

Healthy volunteers

Inclusion criteria

* 19-70 years, * American Society of Anesthesiology physical status 1 and 2 * Scheduled for elective urologic surgery under spinal anesthesia.

Exclusion criteria

* Patients with cardiac and psychological problems. * Patients who take sedatives or narcotics. * Patient who have allergy to study drugs.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of pruritus	24 hours after spinal anesthesia	record of the incidence of pruritus after spinal anesthsia

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026