Chronic Kidney Disease
Conditions
Keywords
Chronic Kidney Disease, Hemodialysis, Peritoneal Dialysis
Brief summary
The EPOCH-RRT study seeks to fill knowledge gaps by gaining more understanding of chronic kidney disease (CKD) patients' priorities; assessing the comparative benefits of hemodialysis (HD) versus peritoneal dialysis (PD), with respect to these priorities; and providing tailored information to assist patients with identifying the best dialysis modality fit for their own unique circumstances and perspectives. The outcomes most relevant to patients (patient-centered) extend beyond those traditionally assessed in clinical research, with the relative importance varying across patient groups. A tailored decision aid based on these findings can improve patient decision-making processes regarding choice of dialysis modality.
Detailed description
Empowering Patients On Choices for Renal Replacement Therapy (EPOCH-RRT)study seeks to identify factors that matter the most to patients with kidney disease and study how they are impacted by different types of dialysis. The inclusion of patients, caregivers, and patient advocacy organizations as research partners will assure that the study addresses questions of greatest relevance to patients facing the need for dialysis. Aim One of EPOCH-RRT identifies outcomes that are most important to different groups of advanced CKD and dialysis patients through qualitative methods applied for conducting in-depth interviews.
Interventions
None listed
Sponsors
University of Michigan
Henry Ford Health System
National Kidney Foundation, United States
American Association of Kidney Patients
Patient-Centered Outcomes Research Institute
Arbor Research Collaborative for Health
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Individuals 18 years of age or older. * Individuals with advanced chronic kidney disease or on dialysis (in-center, hemodialysis, or peritoneal dialysis) for at least three months.
Exclusion criteria
* Individuals under 18 years of age. * Individuals unable to provide informed consent. * Individuals who do not have chronic kidney disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Factors That Are Most Important to Patients | Baseline | Differences in factors most important to patients were compared across chronic kidney disease, hemodialysis, and peritoneal dialysis patients. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Chronic Kidney Disease (CKD) Patients who have advanced chronic kidney disease, but are not currently on either hemodialysis (HD) or peritoneal dialysis (PD). | 65 |
| Hemodialysis (HD) Patients who have chronic kidney disease (CKD) and are currently on hemodialysis. | 77 |
| Peritoneal Dialysis (PD) Patients who have chronic kidney disease (CKD) and are currently on peritoneal dialysis. | 38 |
| Total | 180 |
Baseline characteristics
| Characteristic | Hemodialysis (HD) | Peritoneal Dialysis (PD) | Chronic Kidney Disease (CKD) | Total |
|---|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 22 Participants | 7 Participants | 34 Participants | 63 Participants |
| Age, Categorical Between 18 and 65 years | 55 Participants | 31 Participants | 31 Participants | 117 Participants |
| Age, Continuous | 56.14 years STANDARD_DEVIATION 16.65 | 50.37 years STANDARD_DEVIATION 14.81 | 63.40 years STANDARD_DEVIATION 56.14 | 57.54 years STANDARD_DEVIATION 16.76 |
| Region of Enrollment United States | 77 participants | 38 participants | 65 participants | 180 participants |
| Sex: Female, Male Female | 36 Participants | 20 Participants | 43 Participants | 99 Participants |
| Sex: Female, Male Male | 41 Participants | 18 Participants | 22 Participants | 81 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk |
|---|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — | — / — |
| other Total, other adverse events | 0 / 65 | 0 / 77 | 0 / 38 |
| serious Total, serious adverse events | 0 / 65 | 0 / 77 | 0 / 38 |
Outcome results
Primary
Factors That Are Most Important to Patients
Differences in factors most important to patients were compared across chronic kidney disease, hemodialysis, and peritoneal dialysis patients.
Time frame: Baseline
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Keeping as much independence as possible | 98 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Quality and quantity of life | 100 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Flexibility in daily schedule | 90 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Important to do dialysis at home | 67 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Planned schedule at dialysis center | 68 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Safer to do dialysis at a medical place | 55 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Ability to go to school and work | 43 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Concern about the way you look | 43 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Spending time with patients at dialysis center | 21 % of patients |
| Chronic Kidney Disease (CKD) | Factors That Are Most Important to Patients | Worry about how dialysis will affect others | 43 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Spending time with patients at dialysis center | 52 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Keeping as much independence as possible | 93 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Safer to do dialysis at a medical place | 74 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Planned schedule at dialysis center | 76 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Quality and quantity of life | 89 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Worry about how dialysis will affect others | 33 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Concern about the way you look | 32 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Flexibility in daily schedule | 0 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Ability to go to school and work | 0 % of patients |
| Hemodialysis (HD) | Factors That Are Most Important to Patients | Important to do dialysis at home | 0 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Concern about the way you look | 42 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Important to do dialysis at home | 89 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Planned schedule at dialysis center | 0 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Safer to do dialysis at a medical place | 0 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Spending time with patients at dialysis center | 0 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Ability to go to school and work | 71 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Keeping as much independence as possible | 97 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Worry about how dialysis will affect others | 29 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Quality and quantity of life | 92 % of patients |
| Peritoneal Dialysis (PD) | Factors That Are Most Important to Patients | Flexibility in daily schedule | 94 % of patients |