Embryo Quality, Survival
Conditions
Keywords
vitrification, oocyte, donor, open, closed
Brief summary
The survival rate (and embryo quality) of donor oocytes with two commercially available devices.
Detailed description
Donor sibling oocytes will be vitrified with two commercially available devices. The first device is closed vitrification with closed storage and the second device is open vitrification with closed storage. Oocyte acceptors receive oocytes from both devices. With the increase in cooling rate generated by the open vitrification (second device), we expect to get an increase in survival rate of 10%. Besides this, embryo quality will be assessed with oocytes obtained from both devices.
Interventions
DEVICECBSvit HS device
closed vitrification with closed storage
DEVICECryotop SC device
open vitrification with closed storage
Sponsors
Universitair Ziekenhuis Brussel
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 36 Years
Healthy volunteers
Yes
Inclusion criteria
* Donor: ≤36 years old on day of oocyte retrieval * Donor: ≥ 6 mature oocytes
Exclusion criteria
* Donor: \< 6 mature oocytes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival rate | up to 6 days after every warming cycle | The purpose is to assess the survival rate of donor oocytes with the two vitrification devices. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Embryo development | up to 6 days after every warming cycle | The purpose is to analyse the pre-implantation development of donor oocytes vitrified with two different devices. |
Countries
Belgium
Outcome results
None listed