Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure

Acute Effect of Rg3-enriched Korean Red Ginseng (Steamed Panax Ginseng C.A. Meyer) Standardized Extract on Arterial Stiffness and Aortic and Brachial Blood Pressure in Healthy Individuals

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01951443

Acronym

KRAB

Enrollment

Registered

2013-09-26

Start date

2013-08-31

Completion date

Unknown

Last updated

2014-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arterial Stiffness, Blood Pressure

Keywords

ginseng, clinical trial, vascular, ginsenosides, blood pressure

Brief summary

The purpose of the study is to evaluate the acute effect of a standardized extract of KRG (Rg3-KRG) consisting of 30% total ginsenosides, including 10% Rg3 ginsenoside on arterial stiffness and blood pressure, as measured by the following parameters: aortic augmentation index, peripheral blood pressure, central blood pressure

Interventions

DIETARY_SUPPLEMENTGinseng

400mg of encapsulated Rg3-KRG

DIETARY_SUPPLEMENTWheat Bran

400mg of encapsulated wheat bran

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * Age 18-70 years * BMI \< 30 kg/m2 * Brachial systolic blood pressure \< 140 mmHg * Brachial diastolic blood pressure \< 90 mmHg Main

Exclusion criteria

* BMI \>30kg/m2 * Hypertensive (brachial systolic BP ≥140mmHg and/or diastolic BP ≥90mmHg) * Pregnancy

Design outcomes

Primary

Measure	Time frame
To evaluate the acute effect of Rg3-KRG on arterial stiffness in healthy adult volunteers, as measured by aortic augmentation index (AIx).	Two weeks (measurements taken on two separate visits with minimum one week washout)

Secondary

Measure	Time frame
To evaluate the acute effect of Rg3-KRG on aortic and brachial blood pressure in healthy adult volunteers.	Two weeks (measurements taken on two separate visits with minimum one week washout)

Other

Measure	Time frame
To evaluate the acute safety of Rg3-KRG in healthy adult volunteers using a 48hr symptoms questionnaire.	Two weeks

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026