Healthy
Conditions
Brief summary
This study investigates whole-body distribution kinetics of intravenously administered Gallium-69 (68Ga) citrate by positron emission tomography (PET)/computed tomography (CT). Thereafter, radiation dosimetry of 68Ga-citrate PET/CT will be determined.
Detailed description
Six healthy male volunteers are recruited in this study. Gallium-68 citrate radiopharmaceutical is intravenously injected as a bolus and whole-body distribution kinetics are studied by dynamic whole-body positron emission tomography/computed tomography. During imaging, serial venous blood samples are drawn, plasma is separated and radioactivity is measured by gamma counter. Immediately after imaging session, urine is voided and radioactivity is measured by gamma counting. As a final point, radiation dosimetry due to single Gallium-68 citrate injection is determined.
Interventions
OTHERGallium-68 citrate
Single intravenous bolus injection of 200 MBq of Gallium-68 citrate radiopharmaceutical
Sponsors
Turku University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* healthy 18-100 year-old men
Exclusion criteria
* ongoing infection/inflammation proven by blood or other tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whole-body distribution of Gallium-68 citrate | 4 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Absorbed dose | 4 hours | Absorbed ionisation radiation dose in critical organs due to intravenous bolus injection of 200 MBq of Gallium citrate |
Countries
Finland
Outcome results
None listed