Arrhythmia, ECG Changes, Hypotension
Conditions
Keywords
Digoxin, Intra-amniotic injection, feticide, second trimester abortion
Brief summary
In second trimester abortion above 22 weeks the investigators usually inject intra-cardiac Kcl for feticide. Digoxin intra-amniotic injection has been described in the literature in doses of 1-1.5 mg. with a success rate of about 80%, and up to 24 weeks. Our aim in this study is to investigate the safety and success rate of 1.5-2 mg. digoxin, intra-amniotic up to 30 weeks pregnancy .
Detailed description
* The digoxin will be injected intra-amniotic with U.S guided, trying to avoid any placental passage or intravascular injection / * Any patient will have prior to the procedure a full examination including E.C.G and cardiac clearance.
Interventions
DRUGIntra-amniotic injection of DIGOXIN
Sponsors
Meir Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy women with no medical, cardiac, hypertension, liver or renal problems - pregnant in their 20-30 week gestation, * that need to have abortion due to fetal anomalies or any other reason * need to have feticide prior to the procedure
Exclusion criteria
* any patient with medical problem that may be a contra-indication to Digoxin * cardiac problems, * prior cardiac surgery, * liver or kidney disease, * hyper tension etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficiency of intra-amniotic Digoxin injection for second trimester feticide | a year | To measure the Success rate of intra-amniotic Digoxin injection for feticide prior to second trimester abortion |
Countries
Israel
Contacts
Primary ContactZvi Klein, M.D
Backup ContactRegina agizim, M.D.
Outcome results
None listed