Pain, Surgery
Conditions
Keywords
gene polymorphism, pain perception, postoperative pain
Brief summary
Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.
Detailed description
Subjects with the following diseases were excluded: known history of chronic disease, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, Pregnancy or at lactation period .
Interventions
None listed
Sponsors
Xianwei Zhang
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* •Aged 18-65 years * Receiving elective gynecological laparoscopic surgery * Anesthesiologists (ASA) physical status I or II * Agreed to participate the research
Exclusion criteria
* •History of chronic pain * Psychiatric diseases * Diabetes mellitus * Severe cardiovascular diseases * Kidney or liver diseases * Alcohol or drug abuse * Heavy smoker * Pregnancy or at lactation period * Disagree to participate to the research
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Preoperative Pressure Pain Threshold (PPT) | 30 minutes before the operation | The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say pain when they started to feel pain during the stimulation. The value from the LCD was recorded as the pressure pain threshold. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Preoperative Pressure Pain Tolerance (PTO) | 30 minutes before the operation | The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say ok when they started to feel the pain became intolerable during the stimulation. The value from the LCD was recorded as the pressure pain tolerance. |
Countries
China
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Surgical Patients grouped by receiving surgery | 1,005 |
| Healthy Volunteers Group grouped by healthy college students | 496 |
| Total | 1,501 |
Baseline characteristics
| Characteristic | Surgical Patients | Healthy Volunteers Group | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 11 Participants | 7 Participants | 18 Participants |
| Age, Categorical >=65 years | 4 Participants | 0 Participants | 4 Participants |
| Age, Categorical Between 18 and 65 years | 990 Participants | 489 Participants | 1479 Participants |
| Region of Enrollment China | 1005 participants | 496 participants | 1501 participants |
| Sex: Female, Male Female | 1005 Participants | 309 Participants | 1314 Participants |
| Sex: Female, Male Male | 0 Participants | 187 Participants | 187 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 1,005 | 0 / 496 |
| serious Total, serious adverse events | 0 / 1,005 | 0 / 496 |
Outcome results
Primary
Preoperative Pressure Pain Threshold (PPT)
The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say pain when they started to feel pain during the stimulation. The value from the LCD was recorded as the pressure pain threshold.
Time frame: 30 minutes before the operation
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Surgical Patients | Preoperative Pressure Pain Threshold (PPT) | 2.33 kg/cm2 | Standard Deviation 0.97 |
| Healthy Volunteers Group | Preoperative Pressure Pain Threshold (PPT) | 3.24 kg/cm2 | Standard Deviation 1.25 |
Secondary
Preoperative Pressure Pain Tolerance (PTO)
The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say ok when they started to feel the pain became intolerable during the stimulation. The value from the LCD was recorded as the pressure pain tolerance.
Time frame: 30 minutes before the operation
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Surgical Patients | Preoperative Pressure Pain Tolerance (PTO) | 4.65 kg/cm2 | Standard Deviation 1.66 |
| Healthy Volunteers Group | Preoperative Pressure Pain Tolerance (PTO) | 6.38 kg/cm2 | Standard Deviation 2.56 |