Retinitis Pigmentosa
Conditions
Keywords
RP
Brief summary
In this study, markers of oxidative stress will be measured in the aqueous humour and plasma of RP patients compared to controls.
Detailed description
People with Retinitis Pigmentosa have loss of night vision followed by loss of central vision due to damage and death of photoreceptors. One of the mechanisms causing damage is high levels of oxygen in the eye. This damage produces specific biomarkers which can be measured. In this study, these biomarkers will be assessed in people with Retinitis Pigmentosa and compared to controls.
Interventions
Aqueous Samples will be collected for measurement of biomarkers
Sponsors
Johns Hopkins University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Signed informed consent and authorization of use and disclosure of protected health information * Age more than or equal to 18 years * For the study group, patients diagnosed with Retinitis Pigmentosa by the investigators * For the control group, patients undergoing vitreoretinal surgery for macular hole, epiretinal membrane, vitreomacular traction, retinal detachment, neovascular Age-related Macular Degeneration (AMD) and Diabetic Retinopathy will be eligible
Exclusion criteria
* Patients with active or suspected ocular or periocular infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aqueous levels of markers of oxidative stress in patients with RP and controls. | 2 years |
Countries
United States
Outcome results
None listed