Optimization of PEEP for Alveolar Recruitment in ARDS

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01949272

Acronym

OPERA

Enrollment

Registered

2013-09-24

Start date

2013-09-30

Completion date

2016-05-31

Last updated

2016-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS

Keywords

ARDS

Brief summary

Actual setting of PEEP in ARDS is based on tables linked to FiO2, or respiratory system plateau pressure (e.g EXPRESS Study) or set regarding esophageal pressure mesurement and transpulmonary pressure calculation. Opera study should confirm if a setting approach based on esophageal pressure is helpfull for any ARDS patient in ICU without deleterious side-effect.

Interventions

DEVICEesophageal pressure mesurement

EXPRESS study ventilatory setting the optimization of PEEP with esophageal pressure mesurement

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* ARDS Stades 2 and 3 with invasive ventilation (EXPRESS settings) within 3 to 12 hours

Exclusion criteria

* less 18 years, pregnancy, intracardiac shunt, esophageal catheter cons-indicated

Design outcomes

Primary

Measure	Time frame
PaO2/FiO2 ratio	24 hours

Secondary

Measure	Time frame
Vd/Vt ratio	24 hours

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026