The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.

The Comparison of Effect of Four Different Treatment Protocols: Antagonist/Letrozole Protocol, Microdose Flare-up Protocol, Antagonist/Clomiphene Protocol, Antagonist on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization; a Prospective Randomized-controlled Study.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01948804

Enrollment

100

Registered

2013-09-24

Start date

2014-01-31

Completion date

Unknown

Last updated

2014-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Poor Responders Undergoing IVF

Brief summary

The comparison of effect of four different treatment protocols: Antagonist/letrozole protocol, microdose flare-up protocol, Antagonist/clomiphene protocol, Antagonist on IVF outcomes in poor responders undergoing in vitro fertilization; a prospective randomized-controlled study.

Interventions

DRUGGnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG)

DRUGmicrodose flare-up protocol (Lucrin; Abbott + Gonal F, Serono)

DRUGAntagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma)

DRUGGnRH antagonist protocol (Cetrotide, Serono)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 44 Years

Healthy volunteers

Yes

Inclusion criteria

Criteria for definition of poor responders included at least one of the following 1. Anti müllerian hormone \<1.1 ng/ml and/or a previous poor ovarian response (≤3 oocytes with a conventional stimulation protocol). 2. Primary infertile patients 3. BMI≤30 kg/m2 were included this study.

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
clinical pregnancy rates	6 months

Secondary

Measure	Time frame
total number of oocytes retrieved	6 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026