Coronary Artery Disease
Conditions
Keywords
CAD, CIMT, FMD
Brief summary
The purpose of this study is to determine whether garlic in adjunct to conventional medical treatment is effective in improving carotid intima media thickness (CIMT), Flow mediated dilation (FMD) and plasma lipid profile or c-reactive protein of coronary artery disease (CAD) patients.
Interventions
DIETARY_SUPPLEMENTGarlic
Garlic tablet in adjunct to medical treatment
Sponsors
Shahid Beheshti University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* angiography confirmed coronary artery disease * lack of consistent use of the garlic in the last month
Exclusion criteria
Change in type of medication during study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Carotid Intima Media Thickness | 12 weeks | Change from baseline and compared to placebo group in Carotid Intima Media Thickness at 12 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Flow-mediated dilatation | 12 weeks | Change from baseline and compared to placebo group in Flow-mediated dilatation at 12 weeks |
Other
| Measure | Time frame | Description |
|---|---|---|
| plasma levels of Alanine Aminotransferase, Aspartate Aminotransferase, creatinine, lipid profile, C-Reactive Protein | 12 weeks | Change from baseline in plasma levels at 12 weeks |
Countries
Iran
Outcome results
None listed